VALCHLOR® (mechlorethamine) gel is an alkylating drug indicated for the topical treatment of Stage IA and IB mycosis fungoides–type cutaneous T-cell lymphoma (MF-CTCL) in patients who have received prior skin-directed therapy

VALCHLOR application and storage

VALCHLOR gel self application offers flexibility for patient use1

Apply once daily to dry skin icon

Apply once daily to dry skin

Wash hands with soap and water after touching/applying

Caregivers must wear disposable nitrile gloves when applying*

A small amount as a thin layer icon

A small amount as a thin layer

Apply 4 hours before or 30 minutes after showering or bathing

Let dry for 5 to 10 minutes icon

Let dry for 5 to 10 minutes

Treated area should be allowed to dry before covering with clothing

Can be disposed of in household trash icon

Can be disposed of in household trash

Unused VALCHLOR gel, empty tubes, and used application gloves should be discarded in household trash in a manner that prevents accidental application or ingestion by others, including children and pets

*If there is accidental skin exposure to VALCHLOR, caregivers must immediately wash exposed areas thoroughly with soap and water for at least 15 minutes and remove contaminated clothing.

VALCHLOR should be stored in the refrigerator1

  • Store at a temperature between 36ºF and 46ºF (2ºC and 8ºC)
  • Apply immediately or within 30 minutes after removal from the refrigerator. Return to refrigerator immediately after use
  • Keep VALCHLOR in its original box and away from food
  • Unused product should be thrown away after 90 days
  • Keep VALCHLOR gel out of the reach of children

 

Important reminders for patients1

  • VALCHLOR gel should be stored in the refrigerator at a temperature between 36ºF and 46ºF (2ºC and 8ºC)1
  • Moisturizers may be applied to the treated areas 2 hours before or 2 hours after applying VALCHLOR gel1
  • Do not use occlusive dressings on areas of the skin where VALCHLOR was applied1
  • Patients should avoid fire, flame, and smoking until VALCHLOR has dried. VALCHLOR is flammable1
  • If there is accidental skin exposure to VALCHLOR, caregivers must immediately wash exposed areas thoroughly with soap and water for at least 15 minutes and remove contaminated clothing1
  • Study showed it took 6.5 months for 50% of patients to see a response to treatment (≥50% reduction in CAILS score)2

References:

  1. VALCHLOR [package insert]. Iselin, NJ: Helsinn Therapeutics US, Inc.; January 2020.
  2. Lessin SR, Duvic M, Guitart J, et al. Topical chemotherapy in cutaneous T-cell lymphoma: positive results of a randomized, controlled, multicenter trial
    testing the efficacy and safety of a novel mechlorethamine, 0.02%, gel in mycosis fungoides. Arch Dermatol. 2012;E1-E8.